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The causal evidence layer for drug discovery

Data-driven drug discovery needs structured causal evidence to support mechanistic target and biomarker discovery, but this information is locked in the literature.

Galactic AI™ uncovers cause-and-effect relationships between drugs, genes, and diseases, building the mechanistic rationale that makes targets twice as likely to succeed[1].

Publication Patent Clinical trial TargetID PathwayID DiseaseID increases causes 1 source 1 source 2 sources Mechanistic rationale · 3 supporting mentions

For drug discovery and data science teams

For biology teams

Confidence you’re working on the most promising science

  • Mechanistic cause-and-effect data enables teams to understand why a target influences disease biology, not just that an association exists.
  • Multihop, direction-aware cause-and-effect paths link targets, pathways, and diseases, so teams can follow a mechanism from end to end.
  • Every relationship links back to the original literature, providing the explainability that regulatory and scientific teams demand.
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For data science teams

A causal knowledge graph foundation for your AI/ML workflows

  • Relationships and entity annotations delivered as downloadable parquet files to integrate into your own graph, warehouse or ML pipeline.
  • Every relationship comes out typed, directional, resolved to a public identifier and traceable to the sentence it came from.
  • Instant ontology updates to expand your research space without re-processing the entire corpus.
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What you can do with Galactic AI

Target selection and prioritisation

  • Identify novel targets

    Infer drug-target-disease cause-and-effect relationships to ID novel targets and validate existing hypotheses.

  • Prioritise targets on a composite PTS score

    Large-scale target-prioritisation modelling using the full cause-and-effect corpus, to drive success and reduce attrition.

  • Prioritise and triage large gene lists from functional genomic and omic screen hits

    Rank hits by their cause-and-effect evidence to identify those for validation.

  • Reconstruct the target to disease or phenotype causal chain, for mechanistic rationale

    Mechanistic rationale for gene → disease links.

  • Prioritise disease and phenotypes for a target, for indication expansion

    Use data annotations to identify diseases directly connected to a target based on well-established literature evidence.

Pre-clinical

  • Find pharmacodynamic biomarkers that prove drug modulation of target

    Biomarker investigation: reported biomarkers plus causal-pathway inference of candidate biomarkers.

  • Compile a target safety assessment for mechanism related signals, early

    Early safety signals from chemical/drug → adverse effect cause-and-effect relationships across the literature.

  • Stay up to date on the target and disease literature

    Comprehensive literature review, including in less-studied areas.

Galactic AI turns literature into causal evidence

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  1. 1Unstructured documents

    Galactic AI has processed >61M publications, preprints, patents, clinical trials, drug labels and grants.

  2. 2Galactic AI technology

    • Fine-tuned LLMs

      NER and cross-sentence RE, directional and signed

    • Structured and FAIR

      8 relationship classes and 23 entity classes linked to 22 ontologies

    • Database-side post-processing

      Instant ontology mapping

  3. 3Delivery & access

    • Data Download
    • API
    • Web

Ground agentic systems in semantic knowledge from Galactic AI

Galactic AI provides the ontology-aligned layer of citable cause-and-effect evidence that gives any LLM the domain accuracy and evidence coverage foundation models alone lack.

  • Complete

    Across well-characterised targets, Galactic AI retrieved up to 185× more biological relationships than GPT-5, which omitted core facts documented tens of thousands of times.

  • Consistent

    Galactic AI returns the same facts every time, compared to only 28% consistency between repeated queries to GPT-5.

  • Trusted

    Every relationship & annotation links back to its source publication, so biologists can trace and verify each claim instead of trusting an opaque model.

Read the GPT-5 benchmark →
Access to complete raw data sets this solution apart from other existing tools.
Sergi Picart ArmadaSenior Artificial Intelligence Scientist

Almirall

Causal evidence for drug-target decisions.

Galactic AI uncovers cause-and-effect relationships between drugs, genes, and diseases, building the mechanistic rationale that makes targets twice as likely to succeed[1].

References

  1. Morgan, P. et al. Impact of a five-dimensional framework on R&D productivity at AstraZeneca. Nature Reviews Drug Discovery 17, 167-181 (2018). doi.org/10.1038/nrd.2017.244